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| Status |
Public on Sep 15, 2015 |
| Title |
Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with low RNA copy number including platelets. Resulting studies have used RNA-seq in platelets isolated from healthy individuals to characterize the platelet transcriptome. However, platelets, possibly through gene expression changes, contribute to the etiology of and response to cardiovascular disease and events. To address this, we performed the largest human platelet RNA-seq analysis to date in 34 platelet samples: 16 ST-segment elevation myocardial infarction (STEMI), 16 non-STEMI (NSTEMI), and 2 controls.
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| |
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| Overall design |
RNA-seq of platelet samples from 34 individuals: 16 with ST-elevation myocardial infarction (STEMI), 16 with non-STEMI, and 2 non-myocardial infarction controls
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| Contributor(s) |
Eicher JD, Wakabayashi Y, Vitseva O, Esa N, Yang Y, Zhu J, Freedman JE, McManus DD, Johnson AD |
| Citation(s) |
26367242 |
| |
| Submission date |
Feb 06, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Andrew Danner Johnson |
| E-mail(s) |
johnsonad2@nhlbi.nih.gov
|
| Phone |
508-663-4082
|
| Organization name |
National Heart, Lung and Blood Institute
|
| Department |
Cardiovascular Epidemiology and Human Genomics Branch
|
| Lab |
Johnson Lab
|
| Street address |
The Framingham Heart Study
|
| City |
Framingham |
| State/province |
MASSACHUSETTS |
| ZIP/Postal code |
01746 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (34)
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| Relations |
| BioProject |
PRJNA274751 |
| SRA |
SRP053296 |
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