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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 14, 2007 |
| Title |
Expression data from olfactory epithelium of Lip-C-treated mice compared to Lip-O-treated control mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Microarray analysis of gene expression in the olfactory epithelium of macrophage depleted mice to study the role of macrophages in regulating neurodegeneration, neuroprotection, and neurogenesis of olfactory sensory neurons
Keywords: comparison of gene expression level in sham and 48 hr OBX Lip-O mice versus Lip-C mice
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| Overall design |
Olfactory epithelium from LIp-C-treated and Lip-O-treated mice was microdissected for RNA extraction and hybridization on Affymetrix microarrays. We compared levels of gene expression in macrophage-depleted and non-depleted sham and 48 hr OBX mice using a 2x2 ANOVA and pairwise comparisons to identify molecular mechanisms of macrophage-mediated neurodegeneration, neuroprotection, and neurogenesis and to validate the gene expression patterns using real-time RT-PCR and immunohistochemistry
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| Contributor(s) |
Borders AS, Hersh MA, Getchell ML, vanRooijen N, Cohen DA, Stromberg AJ, Getchell TV |
| Citation(s) |
17848607 |
| Submission date |
Dec 15, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Marilyn L. Getchell |
| E-mail(s) |
mgetch@uky.edu
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| Organization name |
University of Kentucky
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| Department |
Anatomy and Neurobiology
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| Lab |
Sanders-Brown Center on Aging
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| Street address |
800 South Limestone St.
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| City |
Lexington |
| State/province |
KY |
| ZIP/Postal code |
40536-0230 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| GSM151586 |
Lip-C-treated 48 hr OBX C57 mouse, biol rep1 |
| GSM151587 |
Lip-C-treated 48 hr OBX C57 mouse, biol rep2 |
| GSM151588 |
Lip-C-treated 48 hr OBX C57 mouse, biol rep3 |
| GSM151589 |
Lip-C-treated sham OBX C57 mouse, biol rep1 |
| GSM151590 |
Lip-C-treated sham OBX C57 mouse, biol rep2 |
| GSM151591 |
Lip-C-treated sham OBX C57 mouse, biol rep3 |
| GSM151592 |
Lip-O-treated 48 hr OBX C57 mouse, biol rep1 |
| GSM151593 |
Lip-O-treated 48 hr OBX C57 mouse, biol rep2 |
| GSM151594 |
Lip-O-treated 48 hr OBX C57 mouse, biol rep3 |
| GSM151595 |
Lip-O-treated sham OBX C57 mouse, biol rep1 |
| GSM151596 |
Lip-O-treated sham OBX C57 mouse, biol rep2 |
| GSM151597 |
Lip-O-treated sham OBX C57 mouse, biol rep3 |
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| Relations |
| BioProject |
PRJNA98581 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE6540_RAW.tar |
47.8 Mb |
(http)(custom) |
TAR (of CEL) |
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