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Series GSE64706 Query DataSets for GSE64706
Status Public on Oct 01, 2015
Title Transcriptome analysis of mouse embryonic fibroblasts of NIPBL-haploinsufficient mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Cohesinopathies are characterized by mutations in the cohesin complex. Mutations in NIPBL, a cohesin loader, result in Cornelia de Lange syndrome (CdLS). CdLS is a congenital genetic disorder distinguished by craniofacial dysmorphism, abnormal upper limb development, delayed growth, severe cognitive retardation, and multiple organ malformations.It has been suggested that CdLS is caused by defects in the cohesin network that alter gene expression and genome organization. However, the precise molecular etiology of CdLS is largely unclear. To gain insights, we sequenced mRNAs isolated from mouse embryonic fibroblasts of both WT and NIPBL-haploinsufficient mice and compared their transcriptomes.
Overall design Examination of gene expression of WT and NIPBL+/- mice by RNA-seq
Contributor(s) Yuen K, Gerton J
Citation(s) 26725122
Submission date Jan 06, 2015
Last update date May 15, 2019
Contact name Jennifer Gerton
Phone 8169264301
Organization name Stowers Institute for Medical Research
Lab Gerton Lab
Street address 1000 E. 50th Street
City Kansas City
State/province Missouri
ZIP/Postal code 64110
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (6)
GSM1577173 WT1
GSM1577174 WT2
GSM1577175 WT3
BioProject PRJNA271694
SRA SRP051733

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Supplementary file Size Download File type/resource
GSE64706_RAW.tar 4.4 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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