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Series GSE63366 Query DataSets for GSE63366
Status Public on Dec 31, 2015
Title The dynamics of chromatin accessibility during EMT
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary The power of our genome-wide survey lies in that we were able to query chromatin accessibility changes concurrently with those in DNA methylation. We identified both opening and closing events, predominantly independent of DNA methylation, in both systems.
Our results have powerful implications for future basic and clinical research on this developmental process and its resurfacing during cancer cell metastasis.
Overall design To address epigenetic changes that mediate EMT, we used two models in the human system: EMT induced by the transcriptional repressor Twist as well as EMT induced by TGF-beta. We performed AcceSssIble on these cells at several time points through the course of the transition and identified genes that need to be repressed to allow for the process.
Contributor(s) You JS, Yang X, Pandian K, Liang G, Jones PA
Citation(s) 29228692
Submission date Nov 17, 2014
Last update date Mar 22, 2019
Contact name Xiaojing Yang
Phone (323)865-0740
Organization name USC/Norris Comprehensive Cancer Center
Street address 1441 Eastlake Ave, Room 7336
City Los Angeles
State/province CA
ZIP/Postal code 90033
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (16)
GSM1547523 HMEC TWIST 0 d NoE
GSM1547524 HMEC TWIST 0 d Sss I
GSM1547525 HMEC TWIST 2 d NoE
BioProject PRJNA267574

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63366_Matrix_signal_intensities_EMT_XJY.txt.gz 87.4 Mb (ftp)(http) TXT
GSE63366_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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