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| Status |
Public on Jan 15, 2015 |
| Title |
Mutation independent activation of the Notch pathway is associated with Lapatinib resistance in Her2+ breast cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We compared untreated HCC1419 cells with Lapatinib resistant HCC1419 cells that were either treated with Lapatinib for only 9 days before harvesting (drug tolerant persisters, DTPs) or were growing in the presence of Lapatinib (>70 days) (drug tolerant expanded persisters, DTEPs). We show that the Notch pathway is significantly over-expressed in DTEPs when compared to untreated cells.
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| |
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| Overall design |
RNA-Seq of HCC1419 cells either untreated, treated with 1μM Lapatinib for 9 days or treated with 1μM Lapatinib for greater than 70 days
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| |
|
| Contributor(s) |
Grifford M, Plastini M, Katzman S, Salama SR, Haussler D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 06, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Mia Grifford |
| E-mail(s) |
mgrifford@gmail.com
|
| Organization name |
UCSC
|
| Street address |
1156 High Street
|
| City |
San |
| State/province |
CA |
| ZIP/Postal code |
95064 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (7)
|
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| Relations |
| BioProject |
PRJNA263155 |
| SRA |
SRP048664 |
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