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| Status |
Public on Jul 16, 2016 |
| Title |
RNA-sequencing study of peripheral blood monocytes for chronic periodontitis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We confirmed immune response as the key mechanism and provided solid evidence for novel genes (e.g., FCAR and CUX1) and distinct biological processes (e.g., endocytosis, cytokine production and apoptosis) as potentially new important factors/mechanisms contributing to chronic periodontitis pathogenesis.
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| Overall design |
We performed an RNA-sequencing (RNA-seq) study of peripheral blood monocytes (PBMs) in 5 non-smoking moderate to severe CP (case) subjects vs. 5 controls. We replicated the DEx transcripts/isoforms using an independent microarray dataset. We also pathway-based analysis on the identified/replicated DEx transcripts/isoforms using DAVID performed (Database for Annotation, Visualization and Integrated Discovery).
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| Contributor(s) |
Liu Y, Maney P, Puri J, Zhou Y, Deng H |
| Citation(s) |
26812355 |
| |
| Submission date |
Sep 17, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Yao-Zhong Liu |
| Organization name |
Tulane University School of Public Health
|
| Department |
Dept. of Biostatistics and Bioinformatics
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| Lab |
Center for Bioinformatics and Genomics
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| Street address |
1440 Canal Street, Suite 2001
|
| City |
New Orleans |
| State/province |
LA |
| ZIP/Postal code |
70112 |
| Country |
USA |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA261294 |
| SRA |
SRP047232 |
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