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| Status |
Public on Aug 30, 2014 |
| Title |
Expression data of genome-length HCV RNA-replicating OL8(3.5Y) cells and OL8(3.5Y)-derived ribavirin-resistant cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Ribavirin (RBV) is a potential partner of interferon-based therapy and recently approved therapy using direct acting antivirals for patients with chronic hepatitis C, However, the precise mechanisms undelying RBV action against hepatitis C virus (HCV) replication are not yet understood. To clarify this point, we established RBV-resistant cell lines from RBV-sensitive HCV RNA-replicating cell line, OL8(3.5Y), and characterized their features.
We used microarrays to compare the gene expression pattern between OL8(3.5Y) cells and three RBV-resistant cells and identified genes commonly altered by more than four-fold among RBV-resistant cells compared with the OL8(3.5Y) cells.
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| Overall design |
Growing cells from RBV-sensitive OL8(3.5Y) and three RBV-resistant cell lines were used for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Satoh S, Kato N |
| Citation(s) |
25699517 |
| |
| Submission date |
Aug 29, 2014 |
| Last update date |
Oct 17, 2019 |
| Contact name |
Shinya Satoh |
| E-mail(s) |
sisatoh@okayama-u.ac.jp
|
| Organization name |
Okayama University
|
| Street address |
2-5-1 Shikata-cho Kita-ku
|
| City |
Okayama |
| ZIP/Postal code |
7008558 |
| Country |
Japan |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA259881 |
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