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Series GSE60864 Query DataSets for GSE60864
Status Public on May 04, 2015
Title Microarray analysis of mouse gene expression in metronomic cyclophosphamide-treated rat glioma 9L xenografts implanted in scid mice
Platform organism Mus musculus
Sample organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Cyclophosphamide (CPA) treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms of innate immune cell mobilization and recruitment, or about the role of DNA damage and cell stress response pathways in eliciting the anti-tumor immune responses linked to tumor regression. To address these questions, we compared untreated and 6-day metronomic cyclophosphamide-treated rat 9L gliosarcoma xenografts by mouse microarray analysis to identify responsive mouse (host) cell-specific factors.
Overall design Rat glioma 9L tumors were implanted sc in scid immunodeficient mice then treated with cyclophosphamide at 140 mg/kg every 6 days. Tumors were collected 6 days after the fourth cyclophosphamide treatment. Tumor RNA was then analyzed on two color Agilent mouse expression microarrays comparing cyclophosphamide-treated RNA to untreated control tumor RNA.
Contributor(s) Doloff JC, Waxman DJ
Citation(s) 25952672
Submission date Aug 27, 2014
Last update date Nov 01, 2017
Contact name David J. Waxman
Organization name Boston University
Department Department of Biology and Bioinformatics Program
Street address 5 Cummington Mall
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (1)
GSM1491392 9L tumor_4th metroCPA (pool JD3 and pool JD4) versus 9L tumor_control (pool JD1 and pool JD2)_Mouse microarray
This SubSeries is part of SuperSeries:
GSE60913 Gene expression in metronomic cyclophosphamide-treated glioma xenografts
BioProject PRJNA259774

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60864_RAW.tar 8.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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