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| Status |
Public on Dec 09, 2015 |
| Title |
Genome-wide analysis of high glucose and DZNep (EZH2 inhibitor) induced gene expression by mouse podocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of DZNep-induced gene expression changes in cultured podocytes. The hypothesis tested in the present study was that DZnep ultimately augments Txnip expression, increasing oxidative stress in podocytes. These results provide important information on the response of podocytes to histone methyltransferase inhibition and a possible mechanism for DZNep action in podocytes.
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| |
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| Overall design |
Total RNA obtained from cultured podocytes subjected to 48 hours in vitro, with or without DZNep.
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| |
|
| Contributor(s) |
Abdalla M, Siddiqi F, Advani A |
| Citation(s) |
26534922 |
| |
| Submission date |
Aug 04, 2014 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Andrew Advani |
| E-mail(s) |
advania@smh.ca
|
| Phone |
4168646060
|
| Organization name |
St. Michael's Hospital
|
| Department |
Medicine
|
| Street address |
6-151 61 Queen Street East
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5C 2T2 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (12)
|
| GSM1464075 |
Podocytes - No DZNep + No High Glucose 48h rep1 |
| GSM1464076 |
Podocytes - No DZNep + No High Glucose 48h rep2 |
| GSM1464077 |
Podocytes - No DZNep + No High Glucose 48h rep3 |
| GSM1464078 |
Podocytes - with DZNep + No High Glucose 48h rep1 |
| GSM1464079 |
Podocytes - with DZNep + No High Glucose 48h rep2 |
| GSM1464080 |
Podocytes - with DZNep + No High Glucose 48h rep3 |
| GSM1464081 |
Podocytes - with High Glucose + DZNep 48h rep1 |
| GSM1464082 |
Podocytes - with High Glucose + DZNep 48h rep2 |
| GSM1464083 |
Podocytes - with High Glucose + DZNep 48h rep3 |
| GSM1464084 |
Podocytes - with High Glucose 48h rep1 |
| GSM1464085 |
Podocytes - with High Glucose 48h rep2 |
| GSM1464086 |
Podocytes - with High Glucose 48h rep3 |
|
| Relations |
| BioProject |
PRJNA257361 |
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