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Series GSE59671 Query DataSets for GSE59671
Status Public on Apr 20, 2015
Title Celecoxib, rofecoxib treated human smooth muscle cells microarray timecourse
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The aim of this data set is to measure the effect of rofecoxib and celecoxib on the transcription profile in an in vitro inflammation model. Transcription profiling was carried out using Affymetrix HG U-133A v2 microarrays.
Overall design Human aortic smooth muscle cells (3F1243) were pre-treated with rofecoxib (500 nM) or celecoxib (500 nM) for two hours and subsequently exposed to IL-1beta (10 ng/ml). Transcription profiling was carried out at several time points of IL-1beta exposure: Four samples at -2 hours. Four samples each of control, celecoxib, and rofecoxib at each time point 0hr, 2hr, 8hr and 24hr. 52 samples in total.
Contributor(s) Ricciotti E, Grosser T, Price TS, Fitzgerald GA
Citation(s) 25915600
Submission date Jul 22, 2014
Last update date Dec 06, 2018
Contact name Emanuela Ricciotti
Organization name University of Pennsylvania
Department Department of Pharmacology/Institute for Translational Medicine and Therapeutics
Lab FitzGerald Lab
Street address 3400 Civic Center Blvd.
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (52)
GSM1442176 hasmc_celecoxib_tp0hr_biological rep1
GSM1442177 hasmc_celecoxib_tp0hr_biological rep2
GSM1442178 hasmc_celecoxib_tp0hr_biological rep3
BioProject PRJNA255902

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59671_RAW.tar 177.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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