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Series GSE59233 Query DataSets for GSE59233
Status Public on May 30, 2016
Title Impaired DNA damage metabolism promotes autoimmunity in TREX1 deficiency 
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Constitutive low level DNA damage is linked to innate immune activation. Hierarchical clustering of over 9000 transcripts revealed remarkably similar profiles in a patient with lupus erythematosus and a patient with AGS with up-regulation of genes involved in DNA damage signaling, p53-inducible genes, senescence-associated genes as well as up-regulation of interferon-stimulated genes. Transcriptional profiling of fibroblasts exposed to oxidative stress showed a marked up-regulation of genes involved in DNA replication/repair and replication licensing in TREX1-deficient cells compared to wild type cells suggesting massive replication stress.
Overall design Comparison of transcriptional profiles of unstressed patient fibroblasts with wild type cells as well as fibroblasts exposed to oxidative stress
Contributor(s) Wolf C, Berndt N, Rapp A, Dobrick-Mattheuer M, Kretschmer S, Krug C, Kurth T, Wieczorek D, Alexopoulou D, Dahl A, Cardoso MC, Günther C, Lee-Kirsch MA
Citation(s) 27230542
Submission date Jul 09, 2014
Last update date May 15, 2019
Contact name Min Ae Lee-Kirsch
Organization name Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
Department Klinik für Kinder- und Jugendmedizin
Lab Molekulare Pädiatrie
Street address Fetscherstr. 74
City Dresden
ZIP/Postal code 01307
Country Germany
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (10)
GSM1431056 WT1 [L2244]
GSM1431057 WT2 [L2248]
GSM1431058 WT1 [L2545]
BioProject PRJNA254790
SRA SRP044181

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Supplementary file Size Download File type/resource
GSE59233_Embo_NCBI.xlsx.gz 5.7 Mb (ftp)(http) XLSX
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Processed data are available on Series record
Raw data are available in SRA

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