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Series GSE5923 Query DataSets for GSE5923
Status Public on Aug 23, 2007
Title Expression data from Aristolochic Acid and Ochratoxin A treated Tsc2 mutant (Eker) and corresponding wild type rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Renal gene expression profiles of Eker and wild type rats, gavaged with AA or OTA, respectively for 1, 3, 7 or 14 days
We used Affymetrix RAE230A microarrays for the analysis of early gene expression changes in the renal cortex_ outer medulla of carcinogen treated Eker and corresponding wild type rats
Keywords: time course
 
Overall design Eker and wild type rats were gavaged daily with OTA (210µg_ kg BW) or AA (10mg_ kg BW), dissolved in 0,1M sodium bicarbonate. Time-matched vehicle controls were gavaged with 0,1M sodium bicarbonate. Following 1, 3, 7, and 14 days of treatment, Narcoren (pentobarbital) anesthetized rats were sacrificed by exsanguination subsequent to retrograde perfusion with PBS. Left kidneys were collected, cross-sectioned into 5mm slices and stored in RNAlater for subsequent RNA isolantion and chip hybridisation
 
Contributor(s) Dietrich DR, Stemmer K, Ellinger-Ziegelbauer H, Ahr H
Citation(s) 17483316
Submission date Sep 27, 2006
Last update date Mar 03, 2017
Contact name Daniel R. Dietrich
E-mail(s) daniel.dietrich@uni-konstanz.de
Phone 0049-7531-883518
Fax 0049-7531-883170
Organization name University of Konstanz
Department Environmental Toxicology
Street address Jakob-Burckhardt-Str. 25
City Konstanz
ZIP/Postal code 78467
Country Germany
 
Platforms (1)
GPL341 [RAE230A] Affymetrix Rat Expression 230A Array
Samples (84)
GSM137556 Eker Kidney AA d1 biological rep1 1
GSM137557 Eker Kidney AA d1 biological rep2 2
GSM137558 Eker Kidney AA d1 biological rep3 3
Relations
BioProject PRJNA97369

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Supplementary data files not provided
Processed data included within Sample table
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