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| Status |
Public on Feb 23, 2015 |
| Title |
Expression data from WIF1 induced LN-229 (GBM cell line) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Glioblastoma is the most aggressive primary brain tumor in adults and due to the invasive nature it cannot be completely removed. We have recently shown that the WNT inhibitory factor 1 (WIF1), a secreted inhibitor of WNTs, is downregulated in glioblastoma and acts as strong tumor suppressor. In search of a mediator for this function differential gene expression profiles of WIF1-expressing cells were performed. MALAT1, a long non-coding RNA and key positive regulator of invasion, emerged as the top downregulated gene. Indeed, knock-down of MALAT1 reduced migration in glioblastoma cells, without effect on proliferation.
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| |
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| Overall design |
LN-229 cells induced with Doxocyclin to express WIF1 were compared to the non-induced control (two biological replicates each)
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| Contributor(s) |
Vassallo I, Zinn P, Lai M, Rajakannu P, Hamou M, Hegi ME |
| Citation(s) |
25772239 |
| |
| Submission date |
Jun 16, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Irene Vassallo |
| Organization name |
CHUV
|
| Street address |
av bugnon 46
|
| City |
lausanne |
| State/province |
vaud |
| ZIP/Postal code |
1011 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (4)
|
| GSM1412994 |
LN-229 induced WIF1_48h (biological rep. 2) |
|
| Relations |
| BioProject |
PRJNA252828 |
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