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| Status |
Public on Jun 14, 2014 |
| Title |
Expression data from mus musculus subjected to traumatic brain injury (TBI) for treatment with cyclophosphamide |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We inflicted TBI to wildetype (wt) mice in order to establish whether the anti-inflammatory agent cyclophosphamide can be used therapeutically.
Cyclophosphamide was found to regulate distinct inflammatory cells such as activated microglia separate from invading phagocytes and dendritic cells. Cyclophosphamide postinjury selectively reduces antigen-presenting dendritic cells. Findings show feasibility of drug development to interfere with brain inflammation.
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| Overall design |
TBI was carried out in injured wt B6 mice for postinjury treatment with cyclophospamide i.p. using saline as a control substance for comparison with injured but untreated mice. Total RNA was prepared from injured cerebral neocortex after three days. RNA samples were also from uninjured wt mice as reference for hybridization on Affymetrix microarrays.
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| Contributor(s) |
Israelsson C, Ebendal T |
| Citation(s) |
25153123 |
| |
| Submission date |
Jun 13, 2014 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Ted Ebendal |
| E-mail(s) |
Ted.Ebendal@neuro.uu.se
|
| Organization name |
Uppsala University
|
| Department |
Neuroscience
|
| Street address |
Husargatan 3
|
| City |
Uppsala |
| ZIP/Postal code |
75237 |
| Country |
Sweden |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (15)
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| GSM1412408 |
TBI 3 days ipsilateral neocortex wildtype B6 mouse_1 |
| GSM1412409 |
TBI 3 days ipsilateral neocortex wildtype B6 mouse_2 |
| GSM1412410 |
TBI 3 days ipsilateral neocortex wildtype B6 mouse_3 |
| GSM1412411 |
Neocortex uninjured wildtype B6 mouse_1 |
| GSM1412412 |
Neocortex uninjured wildtype B6 mouse_2 |
| GSM1412413 |
Neocortex uninjured wildtype B6 mouse_3 |
| GSM1412414 |
TBI 3 days ipsilateral neocortex cyclophosphamide i.p. wildtype B6 mouse_1 |
| GSM1412415 |
TBI 3 days ipsilateral neocortex, PBS i.p. wildtype B6 mouse_1 |
| GSM1412416 |
TBI 3 days ipsilateral neocortex cyclophosphamide i.p. wildtype B6 mouse_2 |
| GSM1412417 |
TBI 3 days ipsilateral neocortex, PBS i.p. wildtype B6 mouse_2 |
| GSM1412418 |
TBI 3 days ipsilateral neocortex cyclophosphamide i.p. wildtype B6 mouse_3 |
| GSM1412419 |
TBI 3 days ipsilateral neocortex cyclophosphamide i.p. wildtype B6 mouse_4 |
| GSM1412420 |
TBI 3 days ipsilateral neocortex, PBS i.p. wildtype B6 mouse_3 |
| GSM1412421 |
TBI 3 days ipsilateral neocortex cyclophosphamide i.p. wildtype B6 mouse_5 |
| GSM1412422 |
TBI 3 days ipsilateral neocortex, PBS i.p. wildtype B6 mouse_4 |
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| This SubSeries is part of SuperSeries: |
| GSE58485 |
Expression data from mus musculus subjected to traumatic brain injury (TBI) |
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| Relations |
| BioProject |
PRJNA252735 |
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