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Series GSE57976 Query DataSets for GSE57976
Status Public on May 27, 2014
Title Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Antimicrobial peptides (AMPs) are garnering attention as possible alternatives to antibiotics. Here, we describe the antimicrobial properties of epinecidin-1 against multi-drug resistant clinical isolates of P. aeruginosa (P. aeruginosa (R)) and P. aeruginosa from ATCC (P. aeruginosa (19660)) in vivo. The minimum inhibitory concentrations (MICs) of epinecidin-1 against P. aeruginosa (R) and P. aeruginosa (19660) were determined, and compared with those of imipenem. Epinecidin-1 was found to be highly effective at combating peritonitis infection caused by P. aeruginosa (R) or P. aeruginosa (19660) in mouse models, without inducing adverse behavioral effects, or liver or kidney toxicity. Taken together, our results indicate that epinecidin-1 enhances the survival rate of mice infected with the bacterial pathogen P. aeruginosa through both antimicrobial and immunomodulatory effects.
Overall design RNA from mice treated with epinecidin-1 were individually compared to RNA from PBS control mice.
Contributor(s) Chen J, Pan C
Citation(s) 24820078
Submission date May 27, 2014
Last update date Jan 12, 2017
Contact name Jyh-Yih Chen
Phone 886-920802111
Organization name Academia Sinica
Street address 23-10, Dahuen Rd., Jiaushi, Ilan
City Ilan
ZIP/Postal code 262
Country Taiwan
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (4)
GSM1399007 PLE-1
GSM1399008 PLE-2
GSM1399009 N-1
BioProject PRJNA248644

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE57976_RAW.tar 36.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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