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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 12, 2017 |
| Title |
Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
BCAA were administered to atherogenic and high-fat (Ath & HF) diet-induced nonalcoholic steatohepatitis (NASH) model mice and platelet-derived growth factor C transgenic mice (Pdgf-c Tg). Liver histology, tumor incidence, and gene expression profiles were evaluated.
BCAA supplementation improved hepatic steatosis, inflammation, fibrosis, and tumors in the NASH mouse model, possibly through the modification of mTORC1 signaling.
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| Overall design |
Using the Ath & HF diet mouse model, we investigated the effects of BCAA on steatosis, inflammation, fibrosis, and hepatocarcinogenesis in NASH.
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| Contributor(s) |
Takegoshi K, Honda M, Okada H, Matsuzawa-Nagata N, Campbell JS, Takabatake R, Shimakami T, Shirasaki T, Sakai Y, Yamashita T, Takamura T, Tanaka T, Kaneko S |
| Citation(s) |
28212548 |
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| Submission date |
May 05, 2014 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Masao Honda |
| E-mail(s) |
mhondag@gmail.com
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| Phone |
0762652243
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| Organization name |
Kanazawa University
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| Department |
Gastroenterology
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| Street address |
Takara-Machi 13-1
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| City |
Kanazawa |
| ZIP/Postal code |
920-8641 |
| Country |
Japan |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA246197 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE57290_RAW.tar |
60.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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