|
| Status |
Public on May 02, 2014 |
| Title |
Timecourse analysis of Ezh2-dependent gene expression by SVZ NSCs during differentiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Previous work had established that Ezh2-deleted neural stem cells (NSCs) from the postnatal mouse subventricular zone (SVZ) had a deficit in both proliferation and neuronal differentiation both in vivo and in vitro. Ezh2-deleted NSCs in an Ink4a/Arf-deleted background proliferated normally but still displayed a neurogenesis defect, suggesting that Ezh2 is necessary for the proper expression of genes responsible for neuronal differentiation. Our results identify genes that are differentially regulated between control and Ezh2-deleted SVZ NSCs during differentiation.
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| |
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| Overall design |
Total RNA obtained from SVZ NSCs 0, 1, 2, 4, and 7 days after switching from proliferation to differentiation media.
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| |
|
| Contributor(s) |
Hwang WW, Lim DA, Kelley KW, Oldham MC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 23, 2014 |
| Last update date |
Jun 14, 2018 |
| Contact name |
William Hwang |
| Organization name |
UCSF
|
| Department |
Neurosurgery
|
| Lab |
Lim
|
| Street address |
Lim Lab - Box 0525, 35 Medical Center Way
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (24)
|
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| Relations |
| BioProject |
PRJNA245174 |
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