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Series GSE56566 Query DataSets for GSE56566
Status Public on May 25, 2016
Title Transcriptional profiles by deep sequencing (RNA-seq) of papillomas generated using the DMBA/TPA protocol from control and transgenic Nanog overexpressing mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia dramatically promotes the formation of carcinomas upon chemical carcinogenesis. Gene expression analyses in pre-malignant skin indicate that NANOG induces a large set of genes associated to stemness and to epithelial-mesenchymal transition (EMT).
Overall design 4 papillomas from different control mice (CTR), and 3 papillomas from different transgenic Nanog overexpressing mice (TG)
Contributor(s) Palla AR, Graña O, Serrano M
Citation(s) 25988972
Submission date Apr 07, 2014
Last update date May 15, 2019
Contact name Manuel Serrano
Organization name IRB
Department Molecular Medicine
Lab Cellular Plasticity and Disease
Street address Parc Científic de Barcelona, C/ Baldiri Reixac 10
City Barcelona
State/province Barcelona
ZIP/Postal code 08028
Country Spain
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (7)
GSM1364015 CTR rep 1
GSM1364016 CTR rep 2
GSM1364017 TG for Nanog rep 1
BioProject PRJNA243917
SRA SRP041005

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56566_RAW.tar 5.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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