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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 01, 2015 |
| Title |
Candidates for bile acid-dependent PPARĪ±-target genes in mouse intestinal cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In addition to their role as a digestive detergent, bile acids have the ability to modulate the expression of genes. The intestinal content of cholic acids (CA) fluctuated in response to the daily feeding-fasting cycle; therefore, we hypothesized that the temporal accumulation of CA may affect the expression of genes in intestinal epithelial cells. To screen bile acid-regulated genes, we performed oligonucleotide microarray analyses using RNA isolated from the CA-treated intestinal cells of mice. Several types of genes were screened as candidates for bile acid-regulated genes. They included genes that encoded lipid metabolism-related proteins, receptors, transcriptional factors, and plasma-membrane transporters.
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| Overall design |
Total 2 samples were derived from [1] vehicle (0.05% DMSO and 0.25% ethanol)-treated intestinal epithelial cells of mice and [2] cholic acid (CA)-treated intestinal epithelial cells of mice.
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| Contributor(s) |
Koyanagi S, Okamura A, Dilxiat A, Kusunose N, Matsunaga N, Ohdo S |
| Citation(s) |
25422143 |
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| Submission date |
Feb 27, 2014 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Satoru Koyanagi |
| E-mail(s) |
skoyanagi@icloud.com
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| Organization name |
Kyushu University
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| Department |
Pharmaceutics
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| Street address |
3-1-1 Maidashi, Higashi-ku
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| City |
Fukuoka |
| State/province |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA239636 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE55443_RAW.tar |
21.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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