|
| Status |
Public on Oct 01, 2006 |
| Title |
Gene Expression Analysis in Malaria Infection |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Using genome-wide expression profiles from persons either experimentally challenged with malaria-infected mosquitoes or naturally-infected with Plasmodium falciparum malaria, we present details of the transcriptional changes that occur with infection and that are either commonly shared between subjects with pre-symptomatic and clinically apparent malaria or that distinguish these two groups. Our findings confirm and extend aspects of the earliest responses to malaria infection at the molecular level and which may be informative in elucidating how innate and adaptive immune responses may be modulated in different stages of infection.
Keywords: Human PBMC samples from natural and experimentally (clinical trial) induced malaria
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| |
|
| Overall design |
Compared samples from patients with naturally acquired malaria infection to those from volunteers in a challenge model vaccine trial.
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| |
|
| Contributor(s) |
Ockenhouse CF, Vahey MT |
| Citation(s) |
16988231 |
| Submission date |
Jul 31, 2006 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Maryanne Vahey |
| E-mail(s) |
mvahey@hivresearch.org
|
| Phone |
301-251-5058
|
| Fax |
301-762-7460
|
| Organization name |
Walter Reed Army Institute of Research
|
| Department |
|
| Lab |
Laboratory of Functional Genomics
|
| Street address |
1600 East Gude Drive
|
| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20850 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (71)
|
|
| Relations |
| BioProject |
PRJNA96239 |
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