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| Status |
Public on Jan 03, 2014 |
| Title |
Gene array analysis of clear cell renal cell carcinoma tissue versus matched normal kidney tissue |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Currently there is a lack of effective therapies which result in long-term durable response for patients presenting with advanced and metastatic clear cell renal cell carcinoma (ccRCC). This is due in part to a lack of molecular factors which can be targeted pharmacologically. In order to identify novel tumor-specific targets, we performed high throughput gene array analysis screening numerous patient ccRCC tumor tissues across all stages of disease, and compared their gene expression levels to matched normal kidney. Our results identify a number of genes which demonstrate tumor-specific overexpression, and may present as novel targets for therapy.
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| Overall design |
Patient tissue samples were sorted into disease stages based on pathology reports. RNA was extracted from flash frozen patient tumor and normal samples. Gene array analysis was performed, and resulting expression levels were compared between normal and tumor samples.
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| Contributor(s) |
von Roemeling CA, Copland JA, Kolbert C, Tun HW |
| Citation(s) |
24962026 |
| |
| Submission date |
Jan 02, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
John A Copland |
| Organization name |
The Mayo Clinic, Jacksonville FL
|
| Department |
Cancer Research
|
| Lab |
Copland Lab
|
| Street address |
4500 San Pablo Rd
|
| City |
Jacksonville |
| State/province |
Florida |
| ZIP/Postal code |
32224 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (144)
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| Relations |
| BioProject |
PRJNA232816 |
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