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Series GSE53425 Query DataSets for GSE53425
Status Public on Dec 18, 2013
Title SNP data from human fibroblasts and induced Pluripotent Stem cells from Parkinson's Disease patients
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Summary We have generated human induced Pluripotent Stem cells (hiPSc) from Parkinson's Disease patients, using retrovirus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation to dopaminergic neuronal clutures and downstream functional assays.
Fernandes H.J.R., Hartfield E.M., Badger J., Christian H. C., Emmanoulidou E., Vowles J., Evetts S., Vekrellis K., Talbot K., Hu M.T., James W., Cowley S.A., and Wade-Martins, R. Heterozygous glucocerebrosidase mutations in Parkinson's increase autophagic demand, but decrease capacity, in induced pluripotent stem cell-derived dopaminergic neuronal cultures. submitted for publication
Overall design human iPSc lines were derived from human dermal fibroblasts from 2 Parkinson's Disease patients with heterozygous glucocerebrosidase mutations (GBA N370S) mutations, and 2 idiopathic Parkinson's Disease patients. SNP datasets from the 2 control individuals used in this study have been published previously [PMID 23951090 GSE45472; PMID:24586273 GSE43904]
Contributor(s) Fernandes HJ, Hartfield EM, Badger J, Christian HC, Emmanoulidou E, Vowles J, Evetts S, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R
Citation(s) 26905200, 27475716
Submission date Dec 17, 2013
Last update date Dec 18, 2017
Contact name Sally A Cowley
Phone +44 (0) 1865 275600
Organization name University of Oxford
Department Sir William Dunn School of Pathology
Lab James Martin Stem Cell Facility
Street address South Parks Road
City Oxford
ZIP/Postal code OX1 3RE
Country United Kingdom
Platforms (1)
GPL13829 Illumina HumanCytoSNP-12 v2.1 BeadChip
Samples (9)
GSM1291205 GBA-PD 1 fibroblasts
GSM1291206 GBA-PD 1 iPSc clone 1
GSM1291207 GBA-PD 1 iPSc clone 3
This SubSeries is part of SuperSeries:
GSE53426 Gene expression and genotype data from human fibroblasts and induced Pluripotent Stem cells from Parkinson's Disease patients
BioProject PRJNA231957

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Supplementary file Size Download File type/resource
GSE53425_non_normalized.txt.gz 36.2 Mb (ftp)(http) TXT
Processed data included within Sample table

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