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Series GSE53381 Query DataSets for GSE53381
Status Public on Jan 03, 2014
Title Effects of NAFLD/NASH on hepatic gene expression.
Organism Mus musculus
Experiment type Expression profiling by array
Summary To characterize gene expression changes in arachidonic acid metabolism pathway genes in the presense of non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) mice administered were administered an atherogenic diet for a period of four weeks. Administration of the atherogenic diet resulted in significant enrichment of the arachidonic acid metabolism pathway by gene set enrichment analysis (GSEA). The core enrichment subset of genes was down-regulated in mice administered the atherogenic diet and the majority of the genes that were down-regulated were cytochrome P450s.
Overall design A total of 4 wild-type mice were administered a standard diet (STD; control group) and 4 wild-type mice were administered a HFHC diet (HFHC).
Contributor(s) Schuck R, Lee C
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Submission date Dec 16, 2013
Last update date Jan 12, 2017
Contact name Robert Schuck
Phone 734230945
Organization name UNC Chapel Hill
Street address 301 Pharmacy Lane
City Chapel Hill
State/province North Carolina
ZIP/Postal code 27599
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (8)
GSM1290539 Liver_STD_rep1
GSM1290540 Liver_STD_rep2
GSM1290541 Liver_STD_rep3
BioProject PRJNA231871

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53381_RAW.tar 72.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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