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Status |
Public on Sep 22, 2006 |
Title |
whole brains from nicotinic acetylcholine receptor subunit mutant mice and littermate controls |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Avr2 microarray. Keywords: knockout mice, nicotinic acetylcholine receptor
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Overall design |
The experimental groups included six wild-type mice and five beta4-/- mice. All mice were 6-9 weeks old. Total RNA was extracted from whole brain tissue of the mice.
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Contributor(s) |
Orr-Urtreger A, Kedmi M |
Citation(s) |
16985005 |
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Submission date |
Jul 16, 2006 |
Last update date |
Feb 18, 2018 |
Contact name |
Avi Orr-Urtreger |
E-mail(s) |
aviorr@tasmc.health.gov.il
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Phone |
972-3-697-4704
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Fax |
972-3-697-4555
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Organization name |
Tel Aviv Sourasky Medical Center
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Department |
Genetic Institute
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Lab |
Research and Development Laboratory
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Street address |
6 Weizmann St
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City |
Tel Aviv |
ZIP/Postal code |
64239 |
Country |
Israel |
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Platforms (1) |
GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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Samples (11)
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GSM120577 |
Brain_Wild-type_MiceNoLT340 |
GSM120578 |
Brain_Wild-type_MiceNoLT345 |
GSM120579 |
Brain_Wild-type_MiceNoLT346 |
GSM120580 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4363 |
GSM120581 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4365 |
GSM120582 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4398 |
GSM120583 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4424 |
GSM120584 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4437 |
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Relations |
BioProject |
PRJNA96327 |