|
| Status |
Public on Sep 22, 2006 |
| Title |
whole brains from nicotinic acetylcholine receptor subunit mutant mice and littermate controls |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Avr2 microarray.
Keywords: knockout mice, nicotinic acetylcholine receptor
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| |
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| Overall design |
The experimental groups included six wild-type mice and five beta4-/- mice. All mice were 6-9 weeks old. Total RNA was extracted from whole brain tissue of the mice.
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| |
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| Contributor(s) |
Orr-Urtreger A, Kedmi M |
| Citation(s) |
16985005 |
| |
| Submission date |
Jul 16, 2006 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Avi Orr-Urtreger |
| E-mail(s) |
aviorr@tasmc.health.gov.il
|
| Phone |
972-3-697-4704
|
| Fax |
972-3-697-4555
|
| Organization name |
Tel Aviv Sourasky Medical Center
|
| Department |
Genetic Institute
|
| Lab |
Research and Development Laboratory
|
| Street address |
6 Weizmann St
|
| City |
Tel Aviv |
| ZIP/Postal code |
64239 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
|
| Samples (11)
|
| GSM120577 |
Brain_Wild-type_MiceNoLT340 |
| GSM120578 |
Brain_Wild-type_MiceNoLT345 |
| GSM120579 |
Brain_Wild-type_MiceNoLT346 |
| GSM120580 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4363 |
| GSM120581 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4365 |
| GSM120582 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4398 |
| GSM120583 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4424 |
| GSM120584 |
Brain_nAChRbeta4SubunitDeficent_MiceNob4437 |
|
| Relations |
| BioProject |
PRJNA96327 |
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