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| Status |
Public on Aug 25, 2014 |
| Title |
The complete methylome of hematopoietic stem cells and their immediate progeny |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Hematopoietic stem cells (HSCs) constitute a rare cell population in bone-marrow and are capable of live-long self-renewal and production of all mature blood cell types. Cell differentiation processes are governed by epigenetic mechanisms whose study during early differentiation steps will provide insights into stem cell function and differentiation. We performed whole-genome bisulfite sequencing on HSCs and their immediate progeny, namely three different multipotent progenitor subpopulations (MPP1, MPP2, and MPP).
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| |
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| Overall design |
Whole-genome bisulfite sequencing of hematopoietic stem cells (HSCs) and 3 different multipotent progenitor subpopulations (MPP). Three independent biological replicates each were analyzed.
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| Contributor(s) |
Lipka DB, Wang Q, Lier A, Milsom MM, Plass C |
| Citation(s) |
25158935, 25483069 |
| |
| Submission date |
Nov 25, 2013 |
| Last update date |
Jun 07, 2019 |
| Contact name |
Christoph Plass |
| Organization name |
German Cancer Research Center
|
| Street address |
Im Neuenheimer Feld 280
|
| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA229871 |
| SRA |
SRP033304 |
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