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Status |
Public on Dec 31, 2013 |
Title |
The effect of a novel form of macrophage colony-stimulating factor (CSF1-Fc) on gene expression in the liver. |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
|
Summary |
Treatment of mice with daily injections of CSF1-Fc produce a 50% increase in the size of the liver within 5 days. There was extensive proliferation of hepatocytes, similar to that seen following partial hepatectomy.
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Overall design |
Comparative gene expression profiles of the treated and control livers, alongside macrophages grown in CSF1, indicate extensive infiltration by macrophages in response to CSF1-Fc, and demonstrate that infiltrating macrophages produced several candidate mediators of hepatocyte proliferation.
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Contributor(s) |
Gow DJ, Sauter KA, Hume DA |
Citation(s) |
24962162 |
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Submission date |
Nov 21, 2013 |
Last update date |
Jan 08, 2020 |
Contact name |
Kristin Sauter |
E-mail(s) |
kristin.sauter@roslin.ed.ac.uk
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Organization name |
Roslin Institute/The University of Edinburgh
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Street address |
Easter Bush, Midlothian
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City |
Roslin |
ZIP/Postal code |
EH25 9RG |
Country |
United Kingdom |
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Platforms (1) |
GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
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Samples (5)
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GSM1273192 |
Control mouse liver sample replicate 1 |
GSM1273193 |
Control mouse liver sample replicate 2 |
GSM1273194 |
CSF1-Fc treated mouse liver sample replicate 1 |
GSM1273195 |
CSF1-Fc treated mouse liver sample replicate 2 |
GSM1273196 |
CSF1-Fc treated mouse liver sample replicate 3 |
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Relations |
BioProject |
PRJNA229512 |