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| Status |
Public on Dec 05, 2013 |
| Title |
Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. Microarray analysis revealed that a significant proportion of PGC-1alpha-dependent changes in gene expression overlapped with age-associated effects, and aging muscle and muscle lacking PGC-1alpha shared gene signatures of impaired electron transport chain activity and TGFbeta signalling.
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| Overall design |
Gastrocnemius muscle mRNA from young (10 week old) and old (24 month old) wild-type and knock-out (muscle-specific PGC-1alpha, myogenin-cre) C57Bl/6N/6J/129 mice
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| Contributor(s) |
Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL |
| Citation(s) |
24280126 |
| |
| Submission date |
Nov 20, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Benjamin Haibe-Kains |
| E-mail(s) |
benjamin.haibe.kains@utoronto.ca
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| Phone |
+14165818626
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| Organization name |
Princess Margaret Cancer Centre
|
| Department |
Princess Margaret Research
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| Lab |
Bioinformatics and Computational Genomics
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| Street address |
610 University Avenue
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| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5G 2M9 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA229363 |
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