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Series GSE52068 Query DataSets for GSE52068
Status Public on Jan 08, 2016
Title Genome-wide analysis of DNA methylation between nasopharyngeal carcinoma tissues and normal nasopharyngeal epithelial tissues
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Nasopharyngeal carcinoma (NPC) is rare malignancy in most parts around the world but common in Southern China and Southeast Asia, Annually, approximately 80,000 new NPC cases and 50,000 deaths are reported worldwide. In NPC, recent advances have shown that many genes that are predominantly or even exclusively silenced by DNA methylation in epithelial cells during pathogenesis of NPC. However, the causal relationship between DNA methylation status and outcome in NPC remains not well understood. To investigate this problem, we used Illumina 450K BeadChips to examined methylation patterns and survival in NPC. and ultimately provided insight into prognostic value of DNA methylation in NPC clinical management.
 
Overall design We employed Illumina Human Methylation450K Beadchip to analyze a genome-wide of DNA methylation in a cohort of 48 samples (between 24 nasopharyngeal carcinoma tissues and 24 normal nasopharyngeal epithelial tissues) to identify aberrant methylation genes.
 
Contributor(s) Jiang W, Liu N, Chen X, Sun Y, Ma J
Citation(s) 26443805, 28146149
Submission date Nov 04, 2013
Last update date Mar 23, 2020
Contact name Jun Ma
E-mail(s) majun2@mail.sysu.edu.cn
Organization name Sun Yat-sen University Cancer Center
Street address 651 Dongfeng Road East
City Guangzhou
ZIP/Postal code 510060
Country China
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (48)
GSM1258183 genomic DNA from nasopharyngeal carcinoma tissue 1
GSM1258184 genomic DNA from nasopharyngeal carcinoma tissue 2
GSM1258185 genomic DNA from nasopharyngeal carcinoma tissue 3
Relations
BioProject PRJNA226616

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52068_RAW.tar 183.1 Mb (http)(custom) TAR
GSE52068_signal_intensities.txt.gz 65.9 Mb (ftp)(http) TXT
Processed data included within Sample table
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