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Series GSE5180 Query DataSets for GSE5180
Status Public on Jun 28, 2007
Title Gene expression in aortic aneurysms associated with tricuspid and bicuspid valves
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TAV patients with AscAA.
Keywords: disease state analysis
Overall design Aneurysmal tissue of ascending aorta was collected from 13 patients with bicuspid aortic valve (BAV) and 12 patients with tricuspid aortic valve (TAV). Patients were selected on the basis of aortic diameter, age and other disease conditions. Patients with giant cell aortitis, cardiovascular abnormalities, inherited connective tissue disorders such as Marfan and Ehlers-Danlos syndrome were excluded from the study. RNA was extracted using Invitrogen RNA extraction kit and shown to be of adequate quality before application to Affymetrix microarray U133A gene chips probing for over 16,000 genes per chip. Two different methods of data analysis were performed: a linear model and GeneSpring.
Contributor(s) Majumdar R
Citation(s) 17502243
Submission date Jun 28, 2006
Last update date Aug 10, 2018
Contact name Ramanath Majumdar
Phone 507-266-4995
Organization name Mayo Clinic
Street address 200 1st St, SW
City Rochester
State/province MN
ZIP/Postal code 55905
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (25)
GSM116780 Sun176_BAV13 group
GSM116781 Sun177_BAV13 group
GSM116782 Sun178_BAV13 group
BioProject PRJNA96599

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