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| Status |
Public on Dec 31, 2013 |
| Title |
Genome-wide screening and identification of long noncoding RNAs and their interaction with protein coding RNAs in bladder urothelial cell carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
To understand the role of long non-coding RNAs and interaction with coding RNAs in bladder urothelial cell carcinoma (BUCC), we performed genome-wide screening long non-coding RNAs and coding RNAs expression on primary BUCC tissues and normal tissues using long non-coding RNA array (Agilent plateform (GPL13825). By comparing these two groups, significantly differentially expressed lncRNAs and coding RNAs were identified. We further identifed a subset of long noncoding RNAs and their correlation with neighboring coding genes using bioinformatic tools. This analysis provides foundamental understaning of transcriptomic landscape changing during bladder carcinogenesis.
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| Overall design |
12 BUCC primary tumors and 3 normal tissues were used for long noncoding RNA array experiments which including long non-coding RNAs and coding RNAs. The differential expression of subset of long noncoding RNAs and their interaction with coding RNAs in BUCC compared with normal tissue will be identified with comtational analysis.
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| Contributor(s) |
Cheng W |
| Citation(s) |
24705305 |
| |
| Submission date |
Oct 21, 2013 |
| Last update date |
Feb 01, 2019 |
| Contact name |
Wen Cheng |
| E-mail(s) |
Dr_chengwen@126.com
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| Organization name |
Jinling Hospital
|
| Department |
Department of Urology
|
| Street address |
305 Zhong Shan Dong Lu
|
| City |
Nanjing |
| ZIP/Postal code |
210002 |
| Country |
China |
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| Platforms (1) |
| GPL13825 |
Arraystar Human LncRNA microarray V2.0 (Agilent-033010 Feature Number version) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA223308 |
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