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| Status |
Public on Jul 14, 2006 |
| Title |
Molecular Correlate to Gleason Grade in Prostate Adenocarcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Twenty-nine radical prostatectomy samples were laser capture microdissected (LCM) to obtain the most common Gleason patterns (patterns 3, 4, and 5) and matched benign adjacent luminal prostate epithelial cells. We performed cDNA microarrays on matched cancer and adjacent normal samples and identified an 86-gene model capable of distinguishing low Gleason grade (pattern 3) from high Gleason grade (pattern 4 and 5) cancers, which contributes a set of potential targets for modulating the development and progression of the lethal prostate cancer phenotype.
Keywords: disease state analysis
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| Overall design |
12 Gleason pattern 3, 12 Gleason pattern 4, and 8 Gleason pattern 5 laser-capture microdissected prostate cancers hybridized with random dye-swaps against patient-matched normal-adjacent controls.
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| Web link |
http://www.pedb.org
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| Contributor(s) |
True L, Coleman I, Hawley S, Huang A, Gifford D, Coleman R, Beer T, Gelman E, Datta M, Mostaghel E, Knudsen B, Lange P, Vessella R, Lin D, Hood L, Nelson PS |
| Citation(s) |
16829574 |
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| Submission date |
Jun 22, 2006 |
| Last update date |
Jan 17, 2013 |
| Contact name |
Denise Mauldin |
| E-mail(s) |
dmauldin@fhcrc.org
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| Phone |
2066673480
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| Fax |
2066672917
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| URL |
http://www.pedb.org
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| Organization name |
Fred Hutchinson Cancer Research Center
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| Department |
Human Biology
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| Lab |
Peter Nelson
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| Street address |
1100 Fairview Ave N D4-100
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| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
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| Platforms (2) |
| GPL3834 |
FHCRC Human Prostate PEDB cDNA Array v4 |
| GPL3836 |
FHCRC Human Prostate PEDB cDNA Array v3 |
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| Samples (32)
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| Relations |
| BioProject |
PRJNA96639 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE5132_RAW.tar |
41.1 Mb |
(http)(custom) |
TAR (of GPR) |
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