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Series GSE5118 Query DataSets for GSE5118
Status Public on Jun 22, 2006
Title Expression data from MOLT4 human cell line
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To compare The pattern of Gene expression by 7-hydroxymethotrexate-resistant human leukemia cells reveals changes designed to preserve intracellular levels of folate and nucleotide biosynthesis
We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.
Keywords: Resistant and non-resistant MOLT4 cell lines
Overall design Treatment of human T-cell leukemia lines to the major plasma metabolite of methotrexate (MTX), 7-hydroxymethotrexate (7-OHMTX), resulted in an acquired resistance as a results of complete loss of folypolyglutamate synthetase (FPGS) activity. To identify the genes associated with MTX and 7-OHMTX resistance, we analyzed the patterns of gene expression profiles by leukemia sublines and compared with parent cells.
Contributor(s) Fotoohi K, Moshfegh A, Albertioni F
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Submission date Jun 21, 2006
Last update date Aug 10, 2018
Contact name Ali Moshfegh
Organization name Karolinska Institutet
Department Oncology and Pathology
Street address Z5:01
City Stockholm
ZIP/Postal code 17176
Country Sweden
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (9)
GSM115539 Control_biological rep1
GSM115540 Control_biological rep2
GSM115541 Control_biological rep3
BioProject PRJNA96613

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