|
| Status |
Public on Jul 22, 2014 |
| Title |
Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Original patient tumor is directly implanted in mice xenografts. Tumor is propagated to multiple mice for conduct of 6 arm treatment trials and control. Therapies are selected based on T0 and F0 genomic profiles.
ICE-T refractory tumor are implanted and additional 6 arm treatment trial and control conducted based on genomic profiles of F2 generation mice to suggested therapies
|
| |
|
| Overall design |
Original patient tumor expanded in F0 mouse generation to F1 generation for multiple arm therapy trial and then refractory tumors implanted for additional multiple arm therapy trial
|
| |
|
| Contributor(s) |
Monks NR, Cherba DM |
| Citation(s) |
24687871 |
| |
| Submission date |
Sep 24, 2013 |
| Last update date |
Mar 25, 2019 |
| Contact name |
David Cherba |
| E-mail(s) |
david.cherba@vai.org
|
| Phone |
616 234 5382
|
| Organization name |
Van Andel Institute
|
| Department |
Bioinformatics and Biostatistic Core
|
| Street address |
333 Bostwick Ave
|
| City |
Grand Rapids |
| State/province |
MI |
| ZIP/Postal code |
49503 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (6)
|
| GSM1239292 |
Rhabdomyosarcoma original tumorgraft F0 |
| GSM1239293 |
Rhabdomyosarcoma ICE-T treated tumorgraft F2 #1 |
| GSM1239294 |
Rhabdomyosarcoma ICE-T treated tumorgraft F2 #2 |
| GSM1239295 |
Rhabdomyosarcoma ICE-T treated tumorgraft F2 #3 Replicate |
| GSM1239296 |
Rhabdomyosarcoma ICE-T treated tumorgraft F2 #3 |
| GSM1239297 |
Rhabdomyosarcoma original patient tumor T0 |
|
| Relations |
| BioProject |
PRJNA221341 |
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