|
| Status |
Public on Nov 18, 2013 |
| Title |
Runx3 function in splenic NK cells (IL-2 or IL-15) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent.
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| Overall design |
To identify Runx3 responsive genes, NK cells were isolated from spleen of WT and Runx3-/- mice . Ten samples (5 WT and 5 Runx3-/-) of freshly isolated NK cells were separately obtained from individual mice. Cells were cultured for 7 days with IL-2 or IL-15.
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| |
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| Contributor(s) |
Levanon D, Leshkowitz D, Groner Y |
| Citation(s) |
24236182 |
| |
| Submission date |
Aug 22, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Joseph Lotem |
| E-mail(s) |
joseph.lotem@weizmann.ac.il
|
| Phone |
972-8-934-2342
|
| Organization name |
Weizmann institute of science
|
| Department |
Molecular genetics
|
| Street address |
P.O.B 26
|
| City |
Rehovot |
| ZIP/Postal code |
76100 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE50131 |
The transcription program of Runx3 in natural killer cells and CD8+ T cells |
|
| Relations |
| BioProject |
PRJNA216120 |
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