|
| Status |
Public on Aug 17, 2013 |
| Title |
The transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We demonstrate that transcription factor IRF4 is induced in a T cell receptor (TCR) affinity-dependent manner and functions as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulates the expression of key molecules required for aerobic glycolysis of effector T cells, and is essential for clonal expansion and maintenance of effector function of antigen-specific CD8+ T cells.
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| |
|
| Overall design |
Examination of gene expression profiles in six types of samples
|
| |
|
| Contributor(s) |
Kallies A, Man K, Xin A, Shi W, Nutt SL, Smyth GK |
| Citation(s) |
24056747, 26484137 |
| |
| Submission date |
Aug 16, 2013 |
| Last update date |
Oct 09, 2019 |
| Contact name |
Wei Shi |
| E-mail(s) |
Wei.Shi2@monash.edu
|
| Organization name |
Monash University
|
| Street address |
Wellington Rd
|
| City |
Clayton |
| State/province |
Victoria |
| ZIP/Postal code |
3800 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE49931 |
The transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells |
|
| Relations |
| BioProject |
PRJNA215370 |
| SRA |
SRP028864 |
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