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| Status |
Public on Jan 01, 2014 |
| Title |
miR-34 regulates JARID1A expresion (SK-N-BE2) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
p53 inactivation occurs only rarely in neuroblastoma, although miR-34, a transcriptional target of p53, is often deleted in neuroblastoma, suggesting another way in which p53 signaling might be impaired. In this study we show that miR-34 directly targets and downregulates the Polycomb Repressive Complex 2 (PRC2) and its associated histone demethylase, JARID1A, in a p53-dependent manner,
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| Overall design |
4 samples were transfected with miRNA control or miR-34a, miR-34b, miR-34c into SK-N-BE2 cells.
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| Contributor(s) |
Yang J, Davidoff AM |
| Citation(s) |
36612203 |
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| Submission date |
Aug 13, 2013 |
| Last update date |
Jan 13, 2023 |
| Contact name |
JUN YANG |
| E-mail(s) |
jun.yang2@stjude.org
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| Organization name |
St Jude Children's Research Hospital
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| Department |
Surgery
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| Street address |
262 Danny Thomas Place
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| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA215103 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE49845_RAW.tar |
8.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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