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Series GSE49365 Query DataSets for GSE49365
Status Public on Nov 25, 2013
Title Genome-wide acetylated histone 3 lysine 9 (H3K9ac) in HDAC3-depleted liver rescued with deacectylase-dead HDAC3 mutants
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We found that several deacetylase-dead HDAC3 mutants were able to rescue the metabolic phenotype of HDAC3-depleted livers. Here we profile the histone acetylation in the presence of different HDAC3 mutants in mouse liver.
Overall design Deacetylase-dead HDAC3 mutants, including HAHA, KA, YF and HEBI, were introduced into HDAC3-depleted (Cre) mouse livers by virus along with wild-type (WT) HDAC3 as a control. Livers were harvested at 5 pm (ZT 10) and subjected to ChIP with anti-H3K9ac antibodies followed by deep sequencing.
Contributor(s) Fang B, Feng D, Sun Z, Lazar MA
Citation(s) 24268577
Submission date Jul 30, 2013
Last update date May 15, 2019
Contact name Bin Fang
Organization name University of Pennsylvania
Lab Mitch Lazar
Street address 3400 Civic Center Blvd, Bldg 42
City Philadelphia
ZIP/Postal code 19104
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (8)
GSM1198156 H3K9ac ChIPSeq Cre_cohort1
GSM1198157 H3K9ac ChIPSeq WT_cohort1
GSM1198158 H3K9ac ChIPSeq HAHA_cohort1
BioProject PRJNA213727
SRA SRP028329

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Supplementary file Size Download File type/resource
GSE49365_RAW.tar 1.4 Gb (http)(custom) TAR (of BW)
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Raw data are available in SRA
Processed data provided as supplementary file

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