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| Status |
Public on Jul 20, 2013 |
| Title |
Investigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of titanium dioxide nanoparticles |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we investigated the safety of locally delivered titanium dioxide nanoaprticles at the level of gene expression in the retina. To figure out any definite dose-dependent effect, we injected titanium dioxide nanoparticles into the vitreous cavity of 8-week-old male C57BL/6 mice at the concentration of presumptive therapeutic concentration (PTC; 130.47 ng/ml) and 10 times PTC (1.30 μg/ml).
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| Overall design |
We intravitreally injected PBS or titanium dioxide nanoparticles into the right eyes of 8-week-old male C57BL/6 mice (n = 12 per group). PBS-treated mice were regarded as negative control. Four retinal tissues were pooled into 1 test tube and prepared for further analyses.
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| Contributor(s) |
Jo DH, Kim JH, Son JG, Song NW, Yu YS, Lee TG, Kim JH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jul 19, 2013 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Jeong Hun Kim |
| Organization name |
Seoul National University
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| Lab |
FARB (Fight against Angiogenesis-Related Blindness) Laboratory
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| Street address |
101, Daehak-ro, Jongno-gu
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| City |
Seoul |
| ZIP/Postal code |
110744 |
| Country |
South Korea |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA212777 |
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