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| Status |
Public on Jun 22, 2014 |
| Title |
The affect of specific ablation of Runx3 from Esam splenic dendritic cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Esam/CD4+ dendritic cells are part of the innate immunity essential for priming and activating of CD4+ T cells
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| Overall design |
To identify Runx3 responsive genes Esam dendritic cells were freshly sorted from macs enriched splenic DCs taken from 6 weeks old mice. Four samples from four mice were sorted and analyzed where in each littermates pair consisted of a control and Runx3 conditional KO. Mice lacking Runx3 specifically in the DC compartment were produced by crossing Runx3fl/fl mice onto CD11c-Cre mice. This mating scheme generated Runx3fl/fl/CD11c:Cre (CD11c-DC-Runx3Δ) mice.
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| Contributor(s) |
Dicken J, Leshkowitz D, Groner Y |
| Citation(s) |
24204843 |
| |
| Submission date |
Jul 08, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Yoram Groner |
| E-mail(s) |
yoram.groner@weizmann.ac.il
|
| Organization name |
Weizmann institute of science
|
| Department |
Molecular genetics
|
| Lab |
Groner lab
|
| Street address |
P.O.B 26
|
| City |
Rehovot |
| State/province |
istael |
| ZIP/Postal code |
76100 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE48591 |
Runx3 regulated genes in splenic CD4+ dendritic cells |
|
| Relations |
| BioProject |
PRJNA210762 |
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