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| Status |
Public on Jun 28, 2013 |
| Title |
Host directed activity of Pyrazinamide in Mycobacterium tuberculosis infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). we have used human monocyte and a mouse model of pulmonary TB to investigate whether treatment with PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response during Mycobacterium tuberculosis (Mtb) infection.
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| Overall design |
Mice were infected with Mtb and treatment with PZA was started at 28 days post-infection. At 42 days and 63 days post-infection, group of animals were euthanized and lung tissue was collected to isolate total RNA and used in microarray experiments. Mtb-infected, untreated animals served as controls.
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| Contributor(s) |
Subbian S, Koo M, Kaplan G |
| Citation(s) |
24015316 |
| |
| Submission date |
Jun 17, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Selvakumar Subbian |
| E-mail(s) |
subbiase@njms.rutgers.edu
|
| Phone |
973-854-3226
|
| Organization name |
PHRI, NJMS, Rutgers the State University of NJ
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| Department |
Medicine
|
| Lab |
Laboratory of Mycobacterial Immunity and Pathogenesis
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| Street address |
225 Warren Street
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA208723 |
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