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| Status |
Public on Jun 06, 2013 |
| Title |
Genome-wide expression profiling of complex regional pain syndrome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
we successfully identified pain-related genes through genome-wide expression profiling in blood from CRPS patients. We found that 80 genes were differentially expressed between 4 CRPS patients (2 CRPS I and 2 CRPS II) and 5 controls (cut-off value: 1.5-fold change and p < 0.05). Most of those genes were associated with signal transduction, developmental processes, cell structure and motility, and immunity and defense. The expression levels of 12 genes selected from the microarray were confirmed in 24 CRPS patients and 18 controls by quantitative reverse transcription-polymerase chain reaction. We focused on matrix metalloproteinase 9 (MMP9) that showed statistically significant difference from controls and the highest relative fold change in CRPS II patients to controls by qPCR validation (6.4 ± 2.47 times and p = 0.001).
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| Overall design |
Identification of pain-related genes in peripheral blood of complex regional pain syndrome (CRPS) using cDNA microarray.
Comparative gene expression profiles in peripheral blood of 5 healthy controls and 4 CRPS patients.
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| Contributor(s) |
Jin E, Lee W |
| Citation missing |
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| |
| Submission date |
Jun 03, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
EunHeui Jin |
| E-mail(s) |
sowha1219@hotmail.com
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| Organization name |
Chungnam national university
|
| Street address |
Munhwaro
|
| City |
Daejeon |
| ZIP/Postal code |
301-721 |
| Country |
South Korea |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA206506 |
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