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Series GSE47389 Query DataSets for GSE47389
Status Public on Nov 01, 2013
Title Towards understanding breast cancer mechanisms to metastasize
Organism Homo sapiens
Experiment type Expression profiling by array
Summary How organ-specific metastatic traits accumulate in primary tumors remains unknown. We identified a role of the primary tumor stroma in selecting breast cancer cells that are primed for metastasis in the bone. A fibroblast-rich stroma in breast tumors creates a microenvironment that is similar to that of bone metastases in its abundance of the cytokines CXCL12 and IGF1. Heterogeneous breast cancer cell populations growing in such mesenchymal environment evolve towards a preponderance of clones that thrive on CXCL12 and IGF1. Fibroblast-driven selection of bone metastatic clones in mammary tumors is suppressed by CXCL12 and IGF1 receptor inhibition. Thus, a fibroblast-rich stroma in breast tumors can pre-select bone metastatic seeds, promoting the evolution of metastatic traits and the interplay between a primary tumor and its distant metastases.
 
Overall design Affymetrix U133 Plus2 arrays were hybridized according to the manufacturer's procedure using RNA extracted from 47 primary breast tumors. Specific gene sets were evaluated in this cohort.
 
Contributor(s) Smid M, Zhang XH, Foekens J, Massagué J
Citation(s) 23993096
Submission date May 26, 2013
Last update date Mar 25, 2019
Contact name Marcel Smid
Organization name Erasmus MC
Department Medical Oncology
Street address Dr. Molewaterplein 50
City Rotterdam
ZIP/Postal code PO Box 2040, 3000CA
Country Netherlands
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (47)
GSM1148644 primary breast cancer, sample 9
GSM1148645 primary breast cancer, sample 43
GSM1148646 primary breast cancer, sample 46
Relations
BioProject PRJNA205399

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47389_RAW.tar 218.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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