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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 08, 2013 |
| Title |
Effect of aryl hydrocarbon receptor (Ahr) gene knockout on expression profiles of murine hematopoietic stem cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
As part of a study of the role of the aryl hydrocarbon receptor (Ahr) in maintenance and senescence of hematopoietic stem cells (HSC), global gene expression profiling was done with HSC isolated from Ahr-knockout and wild-type mice. HSC from young-adult (8 wk old) AhR-KO mice had changes in expression of many genes related to HSC maintenance, consistent with the phenotype observed in aging Ahr-KO mice: decreased survival rate, splenomegaly, increased circulating white blood cells, hematopoietic cell accumulation in tissues, anemia, increased numbers of stem/progenitor and lineage-committed cells in bone marrow, decreased erythroid progenitor cells in bone marrow, and decreased self-renewal capacity of HSC.
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| Overall design |
7 samples: 3 Ahr knockout, 4 wild-type
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| Contributor(s) |
Welle S, Singh KP, Gasiewicz TA |
| Citation(s) |
24138668, 30388136 |
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| Submission date |
May 15, 2013 |
| Last update date |
Nov 08, 2018 |
| Contact name |
Stephen Welle |
| E-mail(s) |
swelle@rochester.rr.com
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| Organization name |
University of Rochester
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| Street address |
601 Elmwood Avenue
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| City |
Rochester |
| State/province |
NY |
| ZIP/Postal code |
14642 |
| Country |
USA |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA203200 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE46976_RAW.tar |
54.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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