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| Status |
Public on Sep 13, 2013 |
| Title |
Genome-wide analysis of interferon-stimulated genes in primary cells and immortalized cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of interferon-stimulated genes (ISGs) in various primary cells and immortalized cell lines, following type 1 interferon (IFN) treatment. Some cell types become resistant to HIV-1 infection following type 1 interferon treatment (such as macrophages, THP-1, PMA-THP-1, U87-MG cells and to a lesser extent, primary CD4+ T cells) while others either become only partially resistant (e.g., HT1080, PMA-U937) or remain permissive (e.g., CEM, CEM-SS, Jurkat T cell lines and U937); for more information see (Goujon and Malim, Journal of Virology 2010) and (Goujon and Schaller et al., Retrovirology 2013). We hypothesized that the anti-HIV-1 ISGs are differentially induced and expressed in restrictive cells compared to permissive cells and performed a whole genome analysis following type 1 IFN treatment in cell types exhibiting different HIV-1 resistance phenotypes.
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| Overall design |
48 samples; design: 9 cell lines, primary CD4+ T cells and primary macrophages, untreated and IFN-treated; 2 replicate experiments per cell line; 3 replicate experiments per primary cell type
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| Contributor(s) |
Goujon C, Schulz R, Mirza M, Malim MH |
| Citation(s) |
24048477, 36161446 |
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| Submission date |
May 02, 2013 |
| Last update date |
Dec 01, 2022 |
| Contact name |
Reiner Schulz |
| E-mail(s) |
reiner.schulz@kcl.ac.uk
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| Organization name |
King's College London
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| Department |
Medical & Molecular Genetics
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| Lab |
Epigenetics
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| Street address |
8th floor Guy's Tower
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| City |
London |
| ZIP/Postal code |
SE1 9RT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA201063 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE46599_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE46599_non-normalized_data.txt.gz |
13.8 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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