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| Status |
Public on May 21, 2018 |
| Title |
Gene signature of young, replicative and TNF-α-induced premature senescent of human microvascular endothelial cells-lung (HMVEC-L) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Despite the fact that miRNAs have been extensively investigated for their involvement in diseases, senescence as well as inflammation, miRNAs involved in TNF-α- induced premature senescence remain to be uncovered. Hence, the present study aims to identify unique miRNAs and their respective signaling pathways in TNF-α-induced senescence in lung microvascular endothelial cells and novel targets for prevention or protection against premature senescence and endothelial hyperpermeability. Gene profiling was established using the same RNA input as that used for miRNA profiing. We have employed Agilent Whole Human Genome microarray platform to evaluate the expressions of 19,596 human genes.
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| Overall design |
Gene expression profiles were established for young, replicative and TNF-α-induced premature senescent of HMVEC-L.
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| |
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| Contributor(s) |
Jong H, Mustafa MR, AbuBakar S, Wong P |
| Citation(s) |
28595801 |
| |
| Submission date |
Mar 27, 2013 |
| Last update date |
May 22, 2018 |
| Contact name |
Pooi-Fong Wong |
| Organization name |
University of malaya
|
| Department |
Pharmacology
|
| Street address |
Faculty of Medicine
|
| City |
KUALA LUMPUR |
| ZIP/Postal code |
50603 |
| Country |
Malaysia |
| |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
|
| Samples (8)
|
| GSM1108300 |
HMVEC-L_replicative senescent_rep2 |
| GSM1108301 |
HMVEC-L_replicative senescent_rep3 |
| GSM1108302 |
HMVEC-L_TNF-α-induced premature senescent_rep1 |
| GSM1108303 |
HMVEC-L_TNF-α-induced premature senescent_rep2 |
| GSM1108304 |
HMVEC-L_TNF-α-induced premature senescent_rep3 |
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| This SubSeries is part of SuperSeries: |
| GSE45541 |
Young, replicative and TNF-a-induced premature senescent of human microvascular endothelial cells-lung (HMVEC-L) |
|
| Relations |
| BioProject |
PRJNA194549 |
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