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Series GSE45540 Query DataSets for GSE45540
Status Public on May 21, 2018
Title Gene signature of young, replicative and TNF-α-induced premature senescent of human microvascular endothelial cells-lung (HMVEC-L)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Despite the fact that miRNAs have been extensively investigated for their involvement in diseases, senescence as well as inflammation, miRNAs involved in TNF-α- induced premature senescence remain to be uncovered. Hence, the present study aims to identify unique miRNAs and their respective signaling pathways in TNF-α-induced senescence in lung microvascular endothelial cells and novel targets for prevention or protection against premature senescence and endothelial hyperpermeability. Gene profiling was established using the same RNA input as that used for miRNA profiing. We have employed Agilent Whole Human Genome microarray platform to evaluate the expressions of 19,596 human genes.
Overall design Gene expression profiles were established for young, replicative and TNF-α-induced premature senescent of HMVEC-L.
Contributor(s) Jong H, Mustafa MR, AbuBakar S, Wong P
Citation(s) 28595801
Submission date Mar 27, 2013
Last update date May 22, 2018
Contact name Pooi-Fong Wong
Organization name University of malaya
Department Pharmacology
Street address Faculty of Medicine
ZIP/Postal code 50603
Country Malaysia
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (8)
GSM1108297 HMVEC-L_young_rep1
GSM1108298 HMVEC-L_young_rep2
GSM1108299 HMVEC-L_replicative senescent_rep1
This SubSeries is part of SuperSeries:
GSE45541 Young, replicative and TNF-a-induced premature senescent of human microvascular endothelial cells-lung (HMVEC-L)
BioProject PRJNA194549

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45540_RAW.tar 24.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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