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| Status |
Public on Feb 04, 2014 |
| Title |
Transcriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regulated by GC-C activation and elevation of cGMP in colorectal carcinoma cells. This will help understand the molecular targets and biological pathways regulated by GC-C to bring about cancer cell cytostasis.
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| |
|
| Overall design |
ST (Cy5) Vs. Control (Cy3), ST (Cy5) Vs. Control (Cy3)
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| |
|
| Contributor(s) |
Basu N, Visweswariah SS |
| Citation(s) |
24217248 |
| |
| Submission date |
Mar 27, 2013 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Sandhya S Visweswariah |
| E-mail(s) |
sandhya@mrdg.iisc.ernet.in
|
| Organization name |
Indian Institute of Science
|
| Department |
Molecular Reproduction, Development and Genetics
|
| Street address |
GA-09, Dept of MRDG, Biological Sciences Building, Indian Institute of Science
|
| City |
Bangalore |
| State/province |
Karnataka |
| ZIP/Postal code |
560012 |
| Country |
India |
| |
|
| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
|
| Samples (2) |
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| Relations |
| BioProject |
PRJNA194541 |
