|
| Status |
Public on Mar 14, 2013 |
| Title |
Gene expression alterations due to defective Fbw7-dependent cyclin E ubiquitination in bone marrow erythroid cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
A novel knock-in mouse model was reported (Minella et al., Genes Devel 2008) to have a mixed hyper-proliferative and defective maturation phenotype in the erythroid series. Microarray analyses were performed to identify gene expression alterations resulting from dysregulated cyclin E control.
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| |
|
| Overall design |
Analysis of gene expression changes in cyclin E (T74A T393A) knock-in erythroblasts (Ter119-positive, CD71-high) isolated by FACS sorting. Comparison is to cells similarly isolated from littermate controls.
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| |
|
| Contributor(s) |
Minella A, Xu Y |
| Citation(s) |
23873023 |
| |
| Submission date |
Mar 13, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Yanfei Xu |
| E-mail(s) |
yanfei-xu@northwestern.edu
|
| Organization name |
Northwestern University
|
| Department |
Medicine
|
| Street address |
303 E. Superior Street., Lurie 5-250
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60611 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA192946 |
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