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| Status |
Public on May 29, 2013 |
| Title |
Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However, ventral tegmental area (VTA), a region adjacent to SNpc, is less affected in PD. Until now, molecular mechanisms behind VTA aging have not been fully investigated using high throughput techniques.
Here, aging-associated early changes in transcriptome of VTA were investigated comparing late middle-aged (18 months old) to young (2 months old) mice.
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| Overall design |
Three age groups of C57 wild type mice were used in microarray analysis: young (2 months old), middle aged (10 months old), and late-middle aged (18 months old) mice. Four replicates were included in each age group and each replicate was pooled from 5 mice (5 mice/replicate x 4 replicates x 3 age groups). Total RNA was isolated from VTA for hybridization on Affymetrix microarrays.
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| Contributor(s) |
Gao L, Hidalgo-Figueroa M, Escudero LM, Díaz-Martín J, López-Barneo J, Pascual A |
| Citation(s) |
23638090 |
| |
| Submission date |
Mar 12, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Lin Gao |
| E-mail(s) |
lgao-ibis@us.es
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| Organization name |
Instituto de Biomedicina de Sevilla
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| Street address |
Avda Manuel Siurot, Hospital Virgen del Rocío
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| City |
Seville |
| ZIP/Postal code |
41013 |
| Country |
Spain |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE45045 |
Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area |
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| Relations |
| BioProject |
PRJNA192891 |
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