GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE45035 Query DataSets for GSE45035
Status Public on Apr 20, 2015
Title Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
Organism Mus musculus
Experiment type Expression profiling by array
Summary Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor’s barrier avoidance, startled jumping, and retarded locomotion. Transcripts in hippocampus, amygdala, medial prefrontal cortex, ventral striatum (nucleus acumbens), septal region, corpus striatum, hemi-brain, blood, spleen and heart of stressed and control C57B/6 mice were analyzed using Agilent’s mouse genome-wide arrays.
Overall design C57B6 mice were exposed to SJL aggressor mice for periods of 5 days and 10days (6 hours each day) to induce anxiety/stress which parallels to PTSD in human
Organs, blood and brain regions were collected after 24 hours and 1.5 week of post 5 days social defeat period; and 24 hour and 6 weeks post 10 days social stress period.
Contributor(s) Muhie S, Hammamieh R, Jett M
Citation(s) 25888136, 28534873
Submission date Mar 12, 2013
Last update date Aug 31, 2017
Contact name seid muhie
Organization name USACEHR
Department Systems Biology Enterprise
Street address 568 Doughten Dr
City Fort Detrick
State/province MD
ZIP/Postal code 21702
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (230)
GSM1096084 C_AY_10d_24h-rep1
GSM1096085 C_AY_10d_24h-rep2
GSM1096086 C_AY_10d_24h-rep3
This SubSeries is part of SuperSeries:
GSE68077 Transcriptome characterization of social stressed C57B6 mice exhibiting PTSD like features
BioProject PRJNA192884

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45035_RAW.tar 988.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap