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| Status |
Public on Mar 22, 2006 |
| Title |
response to persistent beta 2-adrenergic receptor signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
These results revealed an unanticipated beneficial therapeutic effect of beta-agonists, PLN downregulation, which acts to diminish airway hyperreactivity. Agents that inhibit PLN, and thus decrease constrictive responses, may act synergistically with the bronchodilating action of beta-agonists.
A number of other genes related to [Ca2+]I are also differentially regulated by beta2AR activity some of which may act to oppose, or augment, the therapeutic efficacy of chronic beta-agonists. These genes or pathways may also represent additional targets in the treatment of asthma and related obstructive lung diseases.
Keywords: genetic modification
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| Overall design |
To ascertain the effects of persistent beta2AR activation on gene expression, cultured airway smooth muscle cells derived from wild-type and transgenic mice overexpressing beta2AR were subjected to DNA microarray analysis
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| Contributor(s) |
McGraw DW, Fogel KM, Kong S, Kranias EG, Aronow BJ, Liggett SB |
| Citation(s) |
16849635 |
| |
| Submission date |
Mar 20, 2006 |
| Last update date |
Jan 17, 2013 |
| Contact name |
Bruce J Aronow |
| E-mail(s) |
bruce.aronow@chmcc.org
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| Phone |
513-636-4865
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| Organization name |
Cincinnati Children's Hospital Medical Center
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| Street address |
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA94497 |
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